A new study shows that patients suffering from psoriatic arthritis (PsA) could have an increased risk of developing a cardiovascular (CV) problem.
According to Ari Polachek, MD, from the University of Toronto, Ontario, Canada, and colleagues the result of their research point to the fact that PsA might be an independent risk factor for developing cardiovascular diseases.
Their study shows that patients suffering from psoriatic arthritis have a 43% higher risk of developing cardiovascular disease as opposed to individuals not suffering from PsA. Furthermore, the risk of developing an incident cardiovascular event was 55% in patients with PsA then that of the general population. The researchers also stated that PsA patients also had increased risk of myocardial infarction, cerebrovascular disease and heart failure.
Some of the results of the study point to a link between psoriatic disease and comorbidities, predominantly CV and metabolic comorbidities. Despite this, the studies made to determine the risk of developing CV events in PsA patients had both positive and negative results. Due to the fact that the studies were inconclusive, Dr. Polachek and his colleagues gathered and synthesized all the information regarding the risk of CV in PsA patients.
The researchers gathered and analyzed all the existent observational studies in order to determine how big is the risk of PsA patients developing CV and cerebrovascular disease compared to the risk of healthy individuals. In order to gather all the necessary studies they searched through various databases for primary studies while excluding the studies that didn’t consisted of a control population without psoriasis and rheumatic afflictions and those that didn’t evaluated CV outcomes. They managed to gather 11 studies that completely met their criteria all of them consisting of a total of 32 973 patients with PsA.
This is how they’ve concluded that patients with PsA had 43% increased risk for a CV disease and a 55% increased risk of CV events.
The statistic which shows PsA patients have a 55% increased risk of cardiovascular events was based on a clinical risk algorithm similar to the Framingham risk score. According to the researchers, these algorithms seem to underestimate the risk of cardiovascular complications in patients with chronic inflammatory conditions such as psoriasis and psoriatic arthritis. In any case, patients with psoriatic arthritis should also be treated in order to prevent any cardiovascular disease.
The results of their study suggest that PsA should be considered an independent risk factor for cardiovascular disease. The study had a pretty large budget, being funded by a Fellowship Grant from Janssen, Canada, as well as the Krembil Foundation and a Canadian Institutes of Health Research fellowship award.